02-03-2020, 02:11 PM
I could see them (Wuhan Institute of Virology, CAS?). Making deletion/insertion mutants using RaTG13 and then assaying for pathogenicity in Vero or huh7 cell lines in vitro. For whatever reason one got loose?
It (the origin sequence) doesn’t have to be a functional part of a domain so much as it should (could, does?) be increasing receptor affinity to ACE2 as you say.
I guess both events (random mutation & engineered insertion) are unlikely, obviously one happened though! Scary to think there are probably other possibilities we aren’t thinking of yet as well.
It (the origin sequence) doesn’t have to be a functional part of a domain so much as it should (could, does?) be increasing receptor affinity to ACE2 as you say.
I guess both events (random mutation & engineered insertion) are unlikely, obviously one happened though! Scary to think there are probably other possibilities we aren’t thinking of yet as well.